If my mother has Alzheimer’s’s, her mother had Alzheimer’s’s and half of her siblings have Alzheimer’s’s how likely is it that I will have Alzheimer’s’s? At what age will I recognize it? How should I prepare?
Some genes may make a person more likely to get the disease. Having an Alzheimer’s parent does not guarantee that you will get it, too. Two types of genes have a role in developing this illness: risk genes and deterministic genes. Both groups had Alzheimer’s disease genetic markers. The gene that causes Alzheimer’s disease to develop later in life is still unknown. Having risk genes makes it more likely to get a disease, but this does not mean that you will get it.
According to recent findings, multiple genes raise a person’s chance of developing Alzheimer’s. APOE-e4 was the first risk gene discovered and is still the most significant. Between 40 and 65% of people with Alzheimer’s have the APOE-e4 gene. One of three frequent variants of the APOE gene is APOE-e4. We get one copy of APOE from each parent: APOE-e2 and APOE-e3. Alzheimer’s disease is more likely to happen in those who have one copy of the APOE-e4 gene.
Even if your parents both have two copies of the same gene, it’s not a sure thing that you will get it. By increasing the risk, APOE-e4 can potentially hasten the development of symptoms. However, having an APOE-e4 allele does not mean you’ll get Alzheimer’s disease. Some persons with APOE-e4 alleles may never get Alzheimer’s, whereas others with Alzheimer’s do not have any APOE-e4 alleles.
Alzheimer’s Disease Genetic Test
Alzheimer’s disease is one of the Common Mental Disorders that endanger the elderly. Blood testing can determine whether or not a person has an APOE-e4 allele; however, it is not a predictor of Alzheimer’s disease. To find people who might be at a higher risk for Alzheimer’s disease, researchers use APOE testing. Testing is now available for the rare genes associated with Alzheimer’s. A genetic test for APOE-e4 does not predict a person’s risk of developing it; it just shows us which genes they have.
According to the researchers, there may be too many factors influencing the disease’s onset and progress for genetic testing to predict it accurately. Scientists don’t think it’s acceptable to test the general population. If you are worried about the signs of Alzheimer’s or changes in your memory, it is crucial to visit your healthcare professional immediately.